02:00 pm
Opening Registration
04:00 pm
Welcome
Magnificent Dean of University of Coimbra, Prof. Doutor Amílcar Falcão
Dean of the Faculty of Pharmacy of the University of Coimbra, Prof. Doutor Fernando Ramos
Chair of Organizing Committee, Gabriela Jorge Da Silva (University of Coimbra, Portugal)
04:15 pm
OPENING LECTURE
“How Acinetobacter and I became close friends”
Harald Seifert (University of Cologne, Germany)
SESSION 1 | Acinetobacter spp.: Epidemiology and One Health (Ep 1H)
Chair: Paul Higgins (University of Cologne, Germany)
Co-chair: Ignasi Roca(University of Barcelona, Spain)
05:00 pm
Keynote Lecture 1
“Ecology of Acinetobacter baumannii – from nature to bedside”
Gottfried Wilharm(Robert Koch-Institute, Berlin, Germany)
05:30 pm
Oral Communications
O1-1
A. baumannii infection in animals: how zoonotic are they?
Amédée André, Julie Plantade, Pauline Durieu, Anne-Sophie Godeux, Céline Pouzot-Nevoret, Xavier Charpentier and, *Maria-Halima Laaberki.
VetAgro Sup, CIRI, CIRI, CIRI, VetAgro Sup, CIRI, VetAgro Sup-CIRI.
O1-2
Acinetobacter baumannii from turkeys reared for meat production and their environment
*A. Schmitz (1, 2), D. Hanke (2, 3), D. Lüschow (1, 2), S. Schwarz (2, 3), P. G. Higgins (4, 5, 6) and A. T. Feßler (2, 3)
(1) Institute of Poultry Diseases, School of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany (2) Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163 Berlin, Germany (3) Institute of Microbiology and Epizootics, Centre for Infection Medicine, School of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany (4) Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50935 Cologne, Germany (5) German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50935 Cologne, Germany (6) Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50935 Cologne, Germany.
O1-3
One Health and pan genomic epidemiology of a superbug
Valeria Mateo-Estrada (1), Ciara Tyrrell (2), Benjamin A. Evans (3), Fiona Walsh (2) and *Santiago Castillo-Ramírez (1)
1) Universidad Nacional Autónoma de México, Cuernavaca, México 2) Maynooth University, Maynooth, Ireland 3) University of East Anglia, Norwich, UK.
O1-4
High proportion and diversity of novel taxa among Acinetobacter isolates from cattle feces
*Martina Kyselková (1), Violetta Shestivska (2), Martina Maixnerová (2), Eva Skřivanová (3), Alexandr Nemec (2)
1 Laboratory of Environmental Microbiology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic; 2 Centre for Epidemiology and Microbiology, National Institute of Public Health, Prague, Czech Republic; 3 Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Prague, Czech Republic.
06:30 pm
Welcome Reception
SESSION 2 | Genetics and Evolution of Acinetobacter spp. (GE)
Chair: Beate Averhoff (Goethe- University Frankfurt/Main, Germany)
Co-chair: Sara Domingues (University of Coimbra, Portugal)
09:00 am
Keynote Lecture 2
“A multi-scale perspective of Acinetobacter evolution”
Ingo Ebersberger (Goethe – University Frankfurt/Main, Germany)
09:30 am
Oral Communications
O2-1
Genomic diversity of carbapenem-resistant Acinetobacter baumannii reveals distinct virulence evolution
*Mor Lurie-Weinberger1, Darya Bychenko1, Alona Keren-Paz1, David Swartz1 and Yehuda Carmeli1,2,3
1National Institute for Antibiotic Resistance and Infection Control, Israel Ministry of Health, Tel Aviv, Israel; 2Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 3Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
O2-2
Structure and regulation of the hemO gene cluster for heme uptake in Acinetobacter baumannii
*D. Visaggio (1, 2, 3), I. Artuso (1), M. Lucidi (1, 2), P. Visca (1, 2, 3)
1 Department of Science, Roma Tre University, Rome, Italy; 2 NBFC, National Biodiversity Future Center, Palermo, Italy; 3 Santa Lucia Foundation IRCCS, Rome, Italy.
O2-3
Genetic manipulation of A. baumannii-infecting bacteriophages to tackle a larger range of capsular types
*Rita Domingues 1,2; Hugo Oliveira 1,2; Joana Azeredo 1,2
1CEB-Centre of Biological Engineering, University of Minho, Braga, Portugal 2LABBELS –Associate Laboratory, Braga/Guimarães, Portugal.
O2-4
Induction and evolutionary conservation of natural transformation in Acinetobacter baumannii
Jason Chirakadavil (1), Ludovic Poiré (1), Fanny Mazzamurro (2), Eduardo Rocha (2), Maria-Halima Laaberki (1), *Xavier Charpentier (1)
1 Centre Internation de Recherche en Infectiologie. Lyon. France; 2 Institut Pasteur, Paris, France.
10:30 am
Coffee Break
SESSION 3 | Bacterial Infections (Inf)
Chair: Mario Feldman (Washington University St Louis, USA)
Co-Chair: Alejandra Mussi (National University of Rosario, Argentina)
11:00 am
Keynote Lecture 3
“New players in biofilm lifestyle in Acinetobacter baumannii”
Emmanuelle Dé (University of Rouen, France)
11:30 am
Oral Communications
O3-1
Dietary zinc deficiency compromises immunity to Acinetobacter baumannii pneumonia
Dziedzom A. Bansah (1), Xiaomei Ren (1), Zachery R. Lonergan (2), Lillian J. Juttukonda (2), Christopher Pinelli (2), Kelli L. Boyd (2), Eric P. Skaar (2), *Lauren D. Palmer (1)
1 University of Illinois Chicago, Chicago, IL USA 2 Vanderbilt University Medical Center, Nashville, TN, USA.
O3-2
Elucidating the role of Acinetobacter calcoaceticus in promoting intestinal inflammation
*Janiece Glover, Brittney D. Browning (3), Taylor D. Ticer (2), Sarah A. Dooley (1), Jessica Digrazia (1), Amy C. Engevik (1), Melinda A. Engevik (1,2)
Regenerative Medicine and Cell Biology (1), Microbiology and Immunology (2), Institute of Psychiatry (3), Medical University of South Carolina, Charleston, SC United States.
O3-3
Epithelial-macrophage communication promotes clearance of Acinetobacter baumannii from the airway
Jisun Kim, Gyu-Lee Kim, *Dane Parker
Department of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
O3-4
Mechanistic insights into the phagocytosis resistance of the WHO priority pathogen Acinetobacter baumannii
*Juliette Van Buylaere (1, 2), Etienne Robino (1, 2), Clémence Whiteway (1, 2) and Charles Van der Henst (1, 2)
1 Microbial Resistance and Drug Discovery/VIB-VUB Center for Structural Biology, Brussels, Belgium; 2 Structural Biology Brussels/Vrije Universiteit Brussel, Brussels, Belgium.
12:30 pm
Lunch
01:30 pm
Poster Session (Topics 1 – 4)
03:00 pm
Round Table: Heterogeneity in Acinetobacter baumannii: pitfall or useful resource?
Chair: Charles Van Der Henst (University of Vrije, Belgium)
04:00 pm
The Acinetobacter baumannii website (Ab-web): A multidisciplinary knowledge hub, communication platform, and workspace
Nabil Karah et al. (Umeå University, 901 87 Umeå, Sweden)
04:10 pm
Coffee Break
SESSION 4 | Antibiotic Resistance Mechanisms (AMR)
Chair: Laurent Poirel (University of Fribourg, Switzerland)
Co-Chair: Nabil Karah (University of Umea, Sweden)
04:30 pm
Keynote Lecture 4
“Multidrug-resistant Acinetobacter baumannii: main resistance mechanisms and novel therapeutic alternatives”
Laurent Poirel (University of Fribourg, Switzerland)
05:00 pm
Oral Communications
O4-1
Phage-mediated transmission of colistin resistance in Acinetobacter baumanni
*M. Lucidi (1, 2), G. Capecchi (2), I. Artuso (2), S. Traditi (2), D. Visaggio (2, 3), F. Imperi (2, 3), P. Visca (2, 3).
1 NBFC, National Biodiversity Future Center, piazza Marina 61, 90133 Palermo, Italy; 2 Department of Science, Roma Tre University, Viale G. Marconi 446, 00146 Rome, Italy; 3 Santa Lucia Foundation IRCCS, Via Ardeatina 306/354, 00179 Rome, Italy
O4-2
Resistome and Virulome of cefiderocol resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt
*Sandra Sanchez-Urtaza1, Ainhoa Molins-Bengoetxea1, Alain Ocampo-Sosa2,3, Marta Hernández4, David Abad4, Mohammed A. El-Kholy5, Sherine M. Shawky6, Itziar Alkorta7, Lucia Gallego1
1Laboratory of Antibiotics and Molecular Bacteriology, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, Spain 2Microbiology Department of Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain 3CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain 4Laboratory of Molecular Biology and Microbiology, One health, Agrarian Technological Institute of Castile and Leon (ITACyL), Valladolid, Spain. 5Department of Microbiology and Biotechnology, Division of Clinical and Biological Sciences, College of Pharmacy, Arab Academy for Science, Technology & Maritime Transport (AASTMT), Alexandria, Egypt 6Medical Research Institute, Alexandria University, Alexandria, Egypt 7Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, Leioa, Spain
O4-3
Transfer of the chromosomally encoded OXA-23 carbapenemase by recombination in Acinetobacter baumannii
*A. Kyriaki Xanthopoulou (1,2), B. Mónica Cerezales (3), C. Alexander T Dilthey (4), D. Julia Wille (1,2), E. Kai Lucaßen (1), F. Harald Seifert (1,2), G. Lucía Gallego (3), H. Paul G Higgins (1,2)
1 Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany 2 German Center for Infection Research, Partner site Bonn-Cologne, Cologne, Germany 3 Acinetobacter baumannii Research Group. Faculty of Medicine and Nursing, Department of Immunology, Microbiology, and Parasitology, University of the Basque Country UPV/EHU, Leioa, Spain 4 Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
O4-4
Increased Intraspecies Transfer of blaCTX-M-1 After Interspecies Acquisition from Salmonella enterica to Acinetobacter baumannii by Natural Transformation
*Tiago Lima (1,2), Gabriela Jorge da Silva (1,2), Sara Domingues (1,2).
1 Faculty of Pharmacy of University of Coimbra, Coimbra, Portugal; 2 Center for Neurosciences and Cell Biology of University of Coimbra, Coimbra, Portugal
07:00 pm
Conference dinner
SESSION 5 | Acinetobacter spp. Pathogenicity (P)
Chair: Phil Rather (Emory University, Atlanta, USA)
Co-chair: Lauren Palmer (University of Illinois, Chicago, USA)
09:00 am
Keynote Lecture 5
“Dissecting the virulence strategies of Acinetobacter baumannii”
Mario Feldman (Washington University St Louis, USA)
09:30 am
Oral Communications
O5-1
Structure and function of Csu-pili from the hospital bacteria Acinetobacter baumannii
*Henri Malmi, Natalia Pakharukova, Minna Tuittila, Sari Paavilainen, Olena Parilova and Anton V. Zavialov
Joint Biotechnology Laboratory, MediCity, Faculty of Medicine, University of Turku, Turku, Finland.
O5-2
Epinephrine exposure facilities the adaptation of Acinetobacter baumannii to hostile host environments and concomitantly promotes the polymicrobial interactions
*H. Le (1), J. Hardouin (1,2), V. Perrot (1), T. Jouenne (1), P. Cosette (1,2), E. Dé (1)
(1) Normandie Univ, UNIROUEN, INSA Rouen, CNRS, Polymers, Biopolymers, Surfaces Laboratory, Rouen, France. (2) PISSARO Proteomic Facility, IRIB, Mont-Saint-Aignan, France.
O5-3
Intracellular Acinetobacter baumannii in vivo: potential roles in UTI and respiratory infections
*Gisela Di Venanzio (1),Jesus S Distel (1), Jennie E Hazen (1,2), Joseph J Mackel (3), David A Rosen (3), Scott J Hultgren (1,2), Mario F Feldman (1)
1 Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. 2 Department of Molecular Microbiology, Center for Women’s Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA. 3 Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO, United States.
O5-4
Desiccation induces apparent death in the pathogenic bacterium Acinetobacter baumannii
*G. Capecchi (1), M. Lucidi (1, 2), D. Visaggio (1, 2, 3), I. Artuso (1), C. Spagnoli (1), L. Persichetti (1), E. Fardelli (1), G. Capellini (1), G. Rampioni (1, 3), L. Leoni (1), F. Imperi (1, 2, 3), P. Visca (1, 3).
1 Department of Science, Roma Tre University, Rome, Italy; 2 NBFC, National Biodiversity Future Center, Palermo, Italy; 3 Santa Lucia Foundation IRCCS, Rome, Italy.
10:30 am
Coffee Break
SESSION 6 | Prevention and Treatment of Acinetobacter spp. Infections (PT)
Chair: Harald Seifert (University of Cologne, Germany)
Co-chair: Hugo Oliveira (University of Minho, Portugal)
11:00 am
Keynote Lecture 6
“Utilising bacteriophages to combat multidrug-resistant Acinetobacter baumannii infections”
Jeremy Barr (Monash University, Melbourne, Australia)
11:30 am
Oral Communications
O6-1
Targeting multidrug-resistant Acinetobacter baumannii to develop next-generation antibiotics
*Anke Breine (1, 2), Els Pardon (2), Jan Steyaert (2), Han Remaut (2) and Charles Van der Henst (1, 2)
1 Microbial Resistance and Drug Discovery/VIB-VUB Center for Structural Biology, Brussels, Belgium; 2 Structural Biology Brussels/Vrije Universiteit Brussel, Brussels, Belgium.
O6-2
OXA-23 β-lactamase Overexpression in Acinetobacter baumannii results in cellular vulnerabilities that can be targeted for new drug development
*Jennifer M Colquhoun, Philip N Rather
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.; Emory Antibiotic Resistance Center, Emory University, Atlanta, Georgia, USA; Research Service, Atlanta VA Medical Center, Decatur, Georgia, USA.
O6-3
Bacteriophage susceptibility in Acinetobacter baumannii – Capsule type as prerequisite to predict phage lysis?
*A. Annika Yanina Classen (1,2,3), B. Christine Rohde (4), C. Clara Rolland (4), D. Maria J. G. T. Vehreschild (3, 5), E. Johannes Wittmann (4), F. Kyriaki Xanthopoulou (1,3), G. Harald Seifert (1,3), H. Paul Higgins (1,3)
1: Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany 2: University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, Cologne, Germany 3: German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany 4: Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH, Inhoffenstr. 7B, 38124 Braunschweig, Germany 5: Department of Internal Medicine, Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany.
O6-4
To Combat Drug-resistant Bacteria from a Chemist’s Point of View
*Anren Hu(1), K. Chang(1,2)
1 Department of Laboratory of Medicine and Biotechnology, College of Medicine, Tzu‐Chi University, Hualien, Taiwan; 2 Department of Laboratory Medicine, Buddhist Tzu‐Chi General Hospital, Hualien, Taiwan
12:30 pm
Lunch
01:30 pm
Poster Session (Topics 5 – 7)
SESSION 7 | Physiology and Metabolism (FisMet)
Chair: Ingo Ebersberger (Goethe- University Frankfurt/Main, Germany)
Co-chair: Cátia Caneiras (University of Lisbon, Portugal)
02:30 pm
Keynote Lecture 7
“The response of Acinetobacter baumannii to stress during the pathogenesis of pneumonia”
Eric Skaar (Vanderbilt University, Nashville, TN, USA)
03:00 pm
Oral Communications
O7-1
Light Signal Transduction and Chronobiology in the Human Pathogen Acinetobacter baumannii: Role of the BfmRS two component system
*B. Perez Mora1; Permingeat, Valentín1; *Mussi, María Alejandra1
1- Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI), CONICET, Rosario, Argentina.
O7-2
Molecular interactions between peptidoglycan integrity maintenance and outer membrane lipid asymmetry in Acinetobacter baumannii
Sinjini Nandy, Misha I. Kazi, *Joseph M. Boll
University of Texas at Arlington, Arlington, US
O7-3
Systematic Dissection of Genetic Vulnerabilities in Acinetobacter baumannii
*R. Ward (1, 2), J. Tran (1, 3), A. Banta (1, 4), E. Bacon (1, 3), W. Rose (5), and J. Peters (1, 4, 6, 7, 8)
1 School of Pharmacy, University of Wisconsin-Madison, USA; 2 Laboratory of Genetics, University of Wisconsin-Madison, USA; 3 Microbiology Doctoral Training Program, University of Wisconsin-Madison, USA; 4 Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, USA; 5 Pharmacy Practice Division, University of Wisconsin-Madison, USA; 6 Department of Bacteriology, University of Wisconsin-Madison, USA; 7 Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, USA; 8 Center for Genomic Science Innovation, University of Wisconsin-Madison, USA.
O7-4
Identification and characterization of a novel pathway for aldopentose degradation in Acinetobacter baumannii ATCC 19606
*Lydia Alberti, Patricia König, Sabine Zeidler, Volker Müller and Beate Averhoff
Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Goethe University Frankfurt, Frankfurt/Main, Germany